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曾勇教授、吴泓教授课题组在Molecular Cancer上发表研究论文,揭示肝癌发生中RNA甲基化修饰的新机制 2020.07.01

JINRI,WOYUANGANZANGWAIKECENGYONGHEWUHONGJIAOSHOUKETIZUZAIZHONGLIUXUELINGYUDINGJIQIKAN《Molecular Cancer》(IF=15.302)FABIAOTIWEI“KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3”DEKEYANLUNZHU,JIESHIm6AJIAJIZHUANYIMEIFUHEWUDIAOKONGYUANJIANKIAA1429ZAIlncRNA GATA3-ASDEYINDAOXIADINGXIANGJIAJIHUADIAOKONGGATA3 pre-mRNACONGERCUJINGANAIXIBAODEZENGZHIHEZHUANYI。

GAIYANJIUYOUHUAXIYIYUANDULIWANCHENG,TONGXUNZUOZHEWEIGANZANGWAIKECENGYONGJIAOSHOU、WUHONGJIAOSHOUHEYUANKEFEIFUYANJIUYUAN,DIYIZUOZHEWEIGANZANGWAIKELANTIANBOSHIHOU。BENYANJIUDEDAOLEGUOJIAZIRANKEXUEJIJIN、HUAXIYIYUAN1•3•5GONGCHENGXIANGMUDENGJIJINDEZHICHI。

GANXIBAOGANAISHIYIZHONGCHANGJIANDEEXINGZHONGLIU。GANAIZAISUOYOUAIZHENGZHONGDEFABINGLVPAIMINGDISIWEI,HUANZHEDESIWANGLVGAOJUDISANWEI。TANSUOZHUNQUEDEZAOQIZHENDUANBIAOZHIWUHEYOUXIAODEZHILIAOBADIANDUIGAISHANGANAIHUANZHEDEYUHOUJUYOUZHONGDADELINCHUANGYIYI。m6AJIAJIHUAXIUSHISHIZHENHESHENGWUZHONGRNAFENZISHANGZUICHANGJIANDEXIUSHIFANGSHI,GUANGFANCANYULERNADEZHUANLU、JIANQIE、FANYI、DAIXIEDENGSHENGMINGGUOCHENG。YANJIUBIAOMING,RNADEm6AXIUSHIZAIDUOZHONGZHONGLIUDEFASHENGHEFAZHANZHONGFAHUILEGUANJIANZUOYONG。

ZAIBENXIANGYANJIUZHONG,GAITUANDUISHOUCIBAODAOLEm6AJIAJIZHUANYIMEIFUHEWUDIAOKONGYUANJIANKIAA1429ZAIGANAIZHONGDEJUTIGONGNENG,FAXIANKIAA1429ZAIGANAIZUZHIZHONGDEBIAODASHUIPINGXIANZHUGAOYUAIPANG,QIEGAOBIAODAKIAA1429DEHUANZHESHENGCUNLVXIANZHUJIAODI。JINYIBUJIEGUOXIANSHI,KIAA1429CUJINLEGANAIXIBAODETINEIHETIWAIZENGZHIHEZHUANYIQIANNENG。TONGGUOMeRIP-seq、RIP-seq、RNA-seqHEFENZISHENGWUXUEJISHU,GAIYANJIUFAXIANKIAA1429ZAIlncRNA GATA3-ASDEYINDAOXIAKEYIDUIGATA3 pre-mRNADE3’UTRJINXINGDINGXIANGJIAJIHUAXIUSHI,CUSHIRNAJIEHEDANBAIHuRCONGGATA3 pre-mRNASHANGJIELI,JINERJIANGDILEGATA3 pre-mRNADEWENDINGXING,XIADIAOLEGATA3DEBIAODASHUIPING,CONGERCUJINGANAIXIBAODEZENGZHI、DIAOWANGDIKANGHEZHUANYI。

GAIYANJIUJIEGUOJIANDINGCHUm6AJIAJIHUAXIUSHIZAIGANAIFASHENGHEZHUANYIZHONGFAHUIZHONGYAODIAOKONGZUOYONGDEFUZAFENZIJIZHI,YOUZHUYUCONGFENZISHUIPINGLIJIEGANAIDEBINGLIGUOCHENGHEQUELIXINDEGANAIFENZIZHENZHIBADIAN。

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作者:兰天 编辑:史杰蔚 周亮 来源:肝脏外科
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