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我院肝脏外科曾勇教授、吴泓教授课题组在Cell Death & Differentiation上发表研究论文 2020.07.08

JINRI,WOYUANGANZANGWAIKECENGYONGHEWUHONGJIAOSHOUKETIZUZAISHENGWUHUAXUEYUFENZISHENGWUXUEDINGJIQIKAN《Cell Death & Differentiation》(IF=10.717)FABIAOTIWEI“TXNDC12 promotes EMT and metastasis of hepatocellular carcinoma cells via activation of β-catenin”DEKEYANLUNZHU,JIESHIDANBAIERLIUJIANYIGOUMEITXNDC12TONGGUOJIHUOβ-cateninCUJINGANAISHANGPI-JIANZHIZHUANHUAHEZHUANYIDEZUOYONGJIJIZHI。

GAIYANJIUYOUHUAXIYIYUANDULIWANCHENG,TONGXUNZUOZHEWEIGANZANGWAIKECENGYONGJIAOSHOU、WUHONGJIAOSHOU,DIYIZUOZHEWEIGANZANGWAIKEYANJIUSHIYUANKEFEIFUYANJIUYUAN、GANZANGWAIKEXIEKUNLINBOSHIHOUHELANTIANBOSHIHOU。BENYANJIUDEDAOGUOJIAZIRANKEXUEJIJIN、SICHUANSHENGKEJITINGZHONGDIANYANFAXIANGMU、HUAXIYIYUAN1•3•5GONGCHENGXIANGMUDENGJIJINDEZHICHI。

GANXIBAOAI(Hepatocellular carcinoma, HCC,YIXIAJIANCHENGGANAI)SHIWOGUOFABINGLVZUIGAODEEXINGZHONGLIUZHIYI,TONGSHIYESHIDAOZHIZHONGLIUHUANZHESIWANGDEZHUYAOYUANYINZHIYI。GANAIDEZHILIAOZHUYAOBAOKUOSHOUSHUQIECHU、GANYIZHI、SHEPINXIAORONGHEJIERUZHILIAODENG。JINGUANYIYOUDUOZHONGZHENDUIXINGDEZHILIAOSHOUDUAN,RANERGANAIHUANZHEDE 5 NIANSHENGCUNLVRENGRANJIAODI,QIZHUYAOYUANYINZHIYISHIZHONGLIUDEZHUANYI。YINCI,YANJIUGANAIZHUANYIGUOCHENGZHONGDEGUANJIANDIAOKONGYINZIDESHENGWUXUEGONGNENGJIQIDIAOKONGJILI,YANFAXINXINGBAXIANGYAOWUZUDUANGANAIDEFASHENGFAZHANJINCHENG,DUIJIANGDIGANAISHUHOUDEZHUANYILV,TIGAOHUANZHEZHANGQIYUHOUJUYOUZHONGYAOYIYI。

CENGYONGJIAOSHOUHEWUHONGJIAOSHOUTUANDUIDEGAIYANJIUJIANDINGCHULEYIGEZAIGANAIZHUANYIGUOCHENGZHONGQIGUANJIANZUOYONGDEFENZI——DANBAIERLIUJIANYIGOUMEITXNDC12。TXNDC12SHIDANBAIERLIUJIANYIGOUMEIJIAZUDEXINCHENGYUAN,MUQIANDUIQIGONGNENGZHIZHISHENSHAO,DANZUIJINLIANGNIANKAISHIYOUSHAOLIANGWENXIANBAODAOTXNDC12DEBUTONGGONGNENG,DANQIZAIZHONGLIUYANJIUZHONGXIANYOUBAODAO,ZAIGANXIBAOFASHENGFAZHANZHONGDESHENGWUXUEGONGNENGHEDIAOKONGWANGLUOYANJIURENGSHIKONGBAI。GAIYANJIUJIEGUOXIANSHI,TXNDC12DEBIAODAZAIGANAIZUZHIZHONGJIAOAIPANGZUZHIGAO,ZAIGAOZHUANYIQIANNENGDEGANAIXIBAOXIZHONGJIAODIZHUANYIQIANNENGDEGANAIXIBAOXIGAO,TONGSHIZAIMENJINGMAIAISHUANHEFEIZHUANYIZAOZHONGJIAOYUANFAZAOGAO,TISHITXNDC12KENENGYUGANAIDEZHUANYIGUOCHENGXIANGGUAN。JINYIBUDEYANJIUJIEGUOZHENGSHITXNDC12ZAITINEIWAIJUNKECUJINGANAIDEZHUANYI。JIZHISHIYANXIANSHI,TXNDC12KETONGGUOYUwnt/β-cateninXINHAOTONGLUDEGUANJIANZHUANLUYINZIβ-cateninXIANGHUZUOYONG,CUJINβ-cateninRUHEJIHUOXIAYOUEMTXIANGGUANFENZIZEB1DEBIAODA,CONGERXIADIAOE-cadherinDEBIAODA,CUJINGANAIXIBAOFASHENGSHANGPI-JIANZHIZHUANHUA,ZUIZHONGDAOZHIGANAIXIBAOQINXIZHUANYINENGLISHANGSHENG。CIWAI,TONGGUODUIDALIANGLINCHUANGGANAIYANGBENZHONGTXNDC12DEBIAODAJINXINGFENXI,JIEGUOXIANSHITXNDC12KEZUOWEIGANAIHUANZHEDEYUHOUYINZI。

GAIYANJIUJIEGUOJIANDINGCHULEDANBAIERLIUJIANYIGOUMEITXNDC12ZAIGANAIZHUANYIZHONGFAHUIDEZHONGYAODIAOKONGZUOYONGJIQIFENZIJIZHI,TONGSHIZHENGMINGLETXNDC12KEZUOWEIGANAIHUANZHEDEYUHOUYINZIHEQIANZAIDEZHILIAOBADIAN。

YUANWENLIANJIE:http://www.nature.com/articles/s41418-019-0421-7

作者:肝脏外科 编辑:史杰蔚 周亮 来源:肝脏外科
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