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华西医院刘玉-陈崇教授团队在 Cancer Discovery上发表文章阐明肿瘤发生新机制 2020.09.30

9YUE26RI,SICHUANDAXUEHUAXIYIYUANSHENGWUZHILIAOGUOJIAZHONGDIANSHIYANSHILIUYU-CHENCHONGJIAOSHOUTUANDUIZAIZHONGLIUXUEGUOJIDINGJIQIKANCancer discovery (YINGXIANGYINZI29.5)SHANGZAIXIANFABIAOLETIWEI“An epigenetic mechanism underlying chromosome 17p deletion-driven tumorigenesis” DEYANJIULUNWEN,CHANMINGLERANSETI17pQUESHICUJINZHONGLIUFASHENGFAZHANDEYIZHONGXINDEBIAOGUANYICHUANXUEJIZHI。

JIYINZUBUWENDINGXINGSHIZHONGLIUDEXIANZHUTEZHENG,QIZHONG90%YISHANGDERENLEIZHONGLIUHANYOURANSETIKAOBEISHUBIANYI。RANSETI17pQUESHISHIZUIWEICHANGJIANDERANSETIBIANYI,BINGYUHUANZHEYUHOUBULIANGMIQIEXIANGGUAN。2016NIAN,LIUYU、CHENCHONGJIAOSHOUZUOWEIGONGTONGDIYIZUOZHE,SICHUANDAXUEWEIDIYIWANCHENGDANWEI,ZAINatureFABIAOYANJIULUNWEN“Deletions linked to TP53 loss drive cancer through p53-independent mechanisms”,SHOUCIZHENGMINGLERANSETIDAPIANDUANQUESHIZUOWEIYIGEZHENGTINENGCUJINZHONGLIUDEFASHENGFAZHAN,BINGZHENGMING17pSHANGHAIYOUp53ZHIWAIDEWEIZHIDEZHONGLIUYIZHIJIYIN(Liu and Chen et al., Nature 2016)。ZAICIJICHUSHANG,LIUYU-CHENCHONGJIAOSHOUTUANDUILIYONGJIYINBIANJI、JIYINGONGCHENGXIAOSHUHERNAGANRAODENGDUOZHONGYICHUANXUESHOUDUAN,JIANDINGLERANSETI17pSHANGXINDEZHONGLIUYIZHIJIYINPHF23。JINER,YANJIUTUANDUILIYONGCo-IP/MS、ChIP-seq、RNA-seqDENGDUOZUXUEFENXI,CHANMINGLEPHF23YUSIN3-HDACDENGXINGCHENGYIGEXINDEBIAOGUANYICHUANXUEDANBAIZHIJIQIPSHFUHEWU,TONGGUOXITONGDIAOKONGZUDANBAIXIUSHIJIHUOXIAYOUJIYINBIAODADEFENZIJIZHI。ZUIHOU,TONGGUOQIFENZIJIZHIDEYANJIU,YANJIUZHETICHUHDACKENENGDUIRANSETI17pQUESHIDEZHONGLIUYOUQIANZAIDEZHILIAOBABIAO。

SICHUANDAXUEHUAXIYIYUANSHIBENLUNWENDEDIYIZUOZHEDANWEIHETONGXUNDANWEI。LUNWENDEDIYIZUOZHEWEISICHUANDAXUEHUAXIYIYUANSHENGWUZHILIAOGUOJIAZHONGDIANSHIYANSHIBOSHISHENGCHENMEIHECHENXUELAN,TONGXUNZUOZHEWEISICHUANDAXUEHUAXIYIYUANSHENGWUZHILIAOGUOJIAZHONGDIANSHIYANSHIDELIUYUJIAOSHOUHECHENCHONGJIAOSHOU。LIUYU-CHENCHONGJIAOSHOUTUANDUIZHANGQIYANJIUZHONGLIUFASHENGJIZHIJIZHILIAO,ZI2014NIANZUJIANYILAI,YISICHUANDAXUEWEIDIYIDANWEIZAINature (YINGXIANGYINZI42.8)、Cancer Discovery (YINGXIANGYINZI29.5)、Blood (YINGXIANGYINZI17.6) DENGQIKANFABIAOLEYIXILIEYANJIULUNWEN。

作者:沈国波 编辑:史杰蔚 周亮 来源:科研三支部
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